Skeletal muscle fibrosis develops in response to desmin deletion
نویسندگان
چکیده
منابع مشابه
Skeletal Muscle Fibrosis in Response to Compliant Muscle Fibers
Muscle fibrosis is a common Orthopaedic problem that results from tissue trauma, degeneration, neurotoxin injection and disuse. However, the interaction between skeletal muscle cells and the components of the extracellular matrix (ECM) that results in development of fibrotic tissue is not well understood. In this study, we have exploited the fact that the skeletal muscle intermediate filament p...
متن کاملTemporal response of desmin and dystrophin proteins to progressive resistance exercise in human skeletal muscle.
We have investigated the adaptations of the cytoskeletal proteins desmin and dystrophin in relationship to known muscular adaptations of resistance exercise. We measured desmin, dystrophin, and actin protein contents, myosin heavy chain (MHC) isoform distribution, muscle strength, and muscle cross-sectional area (CSA) during 8 wk of progressive resistance training or after a single bout of unac...
متن کاملThe Response of Skeletal Muscle-Expressed Neurotrophins to Acute Resistance Exercise in Male Wistar Rats
Background. BDNF and NT-4/5 have been proposed to be involved in the coordinated adaptations of the neuromuscular system to the elevated level of activity, but an activity-dependent expression of neurotrophins in skeletal muscle is not well established. Objectives. We, therefore, investigated the effect of one session of resistance exercise on mRNA expression of some neurotrophins in Slow and ...
متن کاملSkeletal muscle response to tenotomy.
Tenotomy is a commonly encountered clinical entity, whether traumatic or iatrogenic. This article reviews the response of skeletal muscle to tenotomy. The changes are subdivided into molecular, architectural, and functional categories. Architectural disruption of the muscle includes myofiber disorganization, central core necrosis, Z-line streaming, fibrosis of fibers and Golgi tendon organs, ch...
متن کاملDisruption of both nesprin 1 and desmin results in nuclear anchorage defects and fibrosis in skeletal muscle.
Proper localization and anchorage of nuclei within skeletal muscle is critical for cellular function. Alterations in nuclear anchoring proteins modify a number of cellular functions including mechanotransduction, nuclear localization, chromatin positioning/compaction and overall organ function. In skeletal muscle, nesprin 1 and desmin are thought to link the nucleus to the cytoskeletal network....
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ژورنال
عنوان ژورنال: American Journal of Physiology-Cell Physiology
سال: 2012
ISSN: 0363-6143,1522-1563
DOI: 10.1152/ajpcell.00441.2011